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INDUSTRIAL PHD CANDIDATE CANCER IMMUNOTHERAPY / BISPECIFIC ANTIBODIES (BIOLOGY GROUP)

Philochem AG -
Zürich, ZH

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Détails de l'emploi

Qualifications

Niveau Doctorat
Biotechnologie
Anglais
Niveau Master
Italien
Compétences en communication

Description complète du poste

Job Title: INDUSTRIAL PHD CANDIDATE CANCER IMMUNOTHERAPY / BISPECIFIC ANTIBODIES (BIOLOGY GROUP)

Location: Zurich – Switzerland

Department: Others

About us

Philogen is a Swiss-Italian integrated biotechnology company founded in 1996, dedicated to developing innovative biopharmaceuticals for cancer therapy. Philochem AG is the discovery R&D center of the Philogen Group located in Otelfingen (Zurich, Switzerland). Promising preclinical candidates developed at Philochem are subsequently produced at Philogen’s authorized Good Manufacturing Practice (GMP) facilities in Siena (Italy). The Company currently sponsors and coordinates Phase I, II and III prospective clinical trials in Europe and in the United States. Despite the focus on cancer research, the company is also active in discovering innovative therapies for inflammatory conditions.

Philochem operates with four key departments:
– Biology: Discovery of innovative therapeutic proteins.
– Cell Line Development: Development of GMP-ready mammalian cell lines expressing therapeutic proteins.
– Chemistry: Creating diagnostic and therapeutic targeted small organic molecules.
– Mass Spectrometry: Bridging Biology and Chemistry to support the advancement of preclinical and clinical products.

Your Role

We are looking for a highly motivated PhD candidate to join our Biology team as part of an industrial doctoral project in the field of cancer immunotherapy, with a focus on bispecific antibody therapeutics.
In this position, you will contribute to the design, engineering, and characterization of next-generation antibody-based molecules, including bispecific and immunomodulatory formats. Your work will support the preclinical development of novel therapeutic candidates, with the goal of advancing them toward clinical translation. You will apply state-of-the-art techniques in molecular cloning, protein expression, and purification, and conduct a wide range of in vitro assays (e.g., T cell activation, cytotoxicity, flow cytometry) to evaluate biological activity. The project will also include testing selected candidates in an in vivo–relevant model to assess their translational potential. This PhD project is embedded in a collaborative framework between Philochem and a Partner University, combining academia with translational focus.

Your Tasks

Design and generate bispecific antibody constructs using molecular biology approaches
Produce and purify antibody-based molecules in mammalian expression systems
Perform in vitro assays (immune cell assays, reporter systems, binding assays, cytotoxicity)
Test selected candidates in an in vivo–relevant model
Analyze data and contribute to experimental planning and troubleshooting
Present findings regularly within the project team and at scientific meetings
Collaborate with internal experts and academic supervisors across disciplines

Your Profile

Master’s degree (MSc) in Immunology, Biotechnology, Pharmaceutical Sciences, or a related field
Strong interest in cancer immunotherapy and therapeutic antibody development
Hands-on experience in molecular cloning, cell culture, and protein biochemistry
Familiarity with immune cell assays and flow cytometry is desirable
Good communication skills, scientific curiosity, and a proactive mindset
Excellent command of English (written and spoken)

What we offer

A dynamic industrial PhD program at the interface of academic research and biotech innovation
Access to cutting-edge infrastructure and an interdisciplinary research environment
Strong mentoring from both industry and academic supervisors
Opportunities to attend seminars and publish in peer-reviewed journals
A vibrant, collaborative team working on next-generation immunotherapies

How to Apply

Please submit your application including:

CV
Motivation letter
University transcripts
Contact details of at least two referees

Applications will be reviewed on a rolling basis. Please send your application to Dr. Abdullah Elsayed ([email protected])

Interested candidates are kindly asked to send their Curriculum Vitae to the following e-mail address [email protected], specifying the job position of interest authorizing the process of personal data under Italian Legislative Decree 196/03 and General Data Protection EU Regulation (2016/679).

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Affinez votre recherche

scientist, protein expression & purification emplois

INDUSTRIAL PHD CANDIDATE CANCER IMMUNOTHERAPY / BISPECIFIC ANTIBODIES (BIOLOGY GROUP)

Postdoctoral and PhD Positions in Neurotechnology: Drug/Biologics Carrier Formulation & Chemical Engineering for Focused Ultrasound-Mediated Brain Drug Delivery

Position in Sustainable Recycling Processes for Lithium-ion Batteries (m/f/d)

Bioengineer / Molecular Biologist

Lab Technician, Molecular Biology

Principal Applied Scientist

Scientist, Cell-Based & Functional Assays

Research Assistant / Laboratory Manager (50-100%)

Senior Data Scientist, GeminiApp, DeepMind

QC Scientist - Microbiology Pharma (80 - 100%)

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PhD Positions in Neurotechnology: Next Generation Non-invasive Neurotechnologies & Brain Therapies

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Senior Scientist Qualitätskontrolle – Biochemie

Senior Scientist Qualitätskontrolle – Mikrobiologie

R-285629 Senior Scientist Qualitätskontrolle – Chemie

Machine Learning Scientist

Stability Scientist

Scientific Associateship (Theoretical Physics)

Je souhaite recevoir la dernière alerte Emploi pour les postes de ce type : scientist, protein expression & purification

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