Our research uses a molecular systems neurobiology approach to investigate the critical role that distinct spinal cord neuronal populations play in motor function and to understand how these neuronal populations and their microenviroments are altered in pathological conditions such as spinal cord injury and cerebral palsy. We study the aberrant neuronal patterning in the spinal cord using transcriptomic and proteomic approaches linking molecular and cellular changes to behavioural and neurophysiological outcomes. Our overarching goal is to uncover disorder-underlying mechanisms in the spinal cord, and translate this knowldege into the development of novel therapeutic strategies.
We are looking for a candidate with experience in rodent models of neurological disorders, as well as advanced multi-omics approaches and bioinformatics. More specifically, the candidate will use single-nucleus sequencing to profile spinal cord alterations in a rat model of cerebral palsy and, based on these findings, develop and employ a gene therapy in combination with rehabilitation. They will join a multidisciplinary team of neuroscientists, engineers, and computational scientists. Most of the candidate's time will be dedicated to research, but there will also be opportunities to contribute to teaching activities, supervise PhD and Master's projects, and participate in career development activities.
