This postdoctoral position is based in the Department of Dementia and Neurodegeneration at the University Hospital for Geriatric Medicine Felix Platter (UAFP) in Basel. The role offers strong academic and infrastructural links to the Department of Biomedicine and the Department of Clinical Research at the University of Basel, enabling close interaction with leading technology platforms and interdisciplinary research networks. The research group led by Prof. Marc Aurel Busche is seeking a highly motivated and ambitious postdoctoral researcher to develop and apply human neural circuit measures that are sensitive to early stages of Alzheimer’s disease and related disorders, and to link these measures to mechanistic circuit readouts in model systems. The lab combines human neurophysiology (MEG, EEG, and related approaches), cognitive and behavioural paradigms, and computational modelling with high resolution circuit recordings in mice (two photon calcium imaging, high density Neuropixels electrophysiology) and molecular profiling (including spatial transcriptomics). Our goal is to identify translatable circuit signatures of disease vulnerability and progression, and to establish biomarkers that can support early detection and therapeutic monitoring. The post is embedded in a uniquely translational setting at UAFP, with close interaction with clinical services and patient cohorts in the Memory Clinic and Old Age Psychiatry. The post holder will also benefit from active collaborations with Prof. Busche’s group at the UK Dementia Research Institute at University College London, enabling shared projects, methodological exchange, and cross site training. This is an outstanding opportunity to help shape a cross-species circuit biomarker programme at the interface of human disease neuroscience and mechanistic circuit biology, and to develop independent lines of research in a highly collaborative environment.
You will join a dynamic and collaborative research environment spanning UAFP and the University of Basel. You will have the opportunity to shape a cross-species circuit biomarker programme with direct clinical relevance, interact closely with clinicians and clinical researchers at UAFP, and leverage the technology platforms and training opportunities available through the Department of Biomedicine and the Department of Clinical Research. We offer competitive salaries, comprehensive social benefits, and family friendly conditions. Respect for human values, including diversity, equity, and inclusiveness, are guiding principles of our institutions, ensuring an excellent environment to develop your scientific career.
